MISSION, Kansas — Tens of millions of Americans endured bone-chilling temperatures, blizzard conditions, power outages and canceled holiday gatherings Friday from a winter storm that forecasters said was nearly unprecedented in its scope, exposing about 60 percent of the American population to some sort of winter weather advisory or warning.

More than 200 million people were under some form of winter weather advisory or warning on Friday, the National Weather Service said. The weather service’s map “depicts one of the greatest extents of winter weather warnings and advisories ever,” forecasters said in a statement Friday.

More than 3,400 flights within, into or out of America were canceled Friday, according to the tracking site FlightAware, causing more mayhem as travelers try to make it home for the holidays. More than 458,000 homes and businesses were without power Friday morning.

The huge storm stretched from border to border. In Canada, WestJet canceled all flights Friday at Toronto Pearson International Airport, beginning at 9 a.m. And in Mexico, migrants waited near border in unusually cold temperatures as they awaited a Supreme Court decision on whether and when to lift pandemic-era restrictions that prevent many from seeking asylum.

“This is not like a snow day when you were a kid,” President Biden warned Thursday from the Oval Office after a briefing from federal officials. “This is serious stuff.”

Forecasters are expecting a bomb cyclone — when atmospheric pressure drops very quickly in a strong storm — to develop near the Great Lakes. That will stir up blizzard conditions, including heavy winds and snow.

Among those with canceled flights was Ashley Sherrod, who planned to fly to Flint, Michigan, from Nashville, Tennessee, on Thursday afternoon. Sherrod was debating whether to drive or risk booking a Saturday flight that she worries will be canceled.

“My family is calling, they want me home for Christmas, but they want me to be safe, too,” said Ms. Sherrod, whose bag — including the Grinch pajamas she was planning to wear to a family party — was packed and ready by the door. “Christmas is starting to, for lack of a better word, suck.”

The cold also led to a high demand at homeless shelters, including at Detroit, where some shelters were at capacity Thursday.

“We are not sending anyone back into this cold,” a spokeswoman for COTS, a family-only shelter, Aisha Morrell-Ferguson, told the Detroit News.

And at Portland, Oregon, officials opened four emergency shelters. In the city’s downtown, Steven Venus tried to get on a light-rail train to get out of the cold after huddling on the sidewalk overnight in below-zero temperatures.

“My toes were freezing off,” he said, a sleeping bag wrapped around his head, as he paused near a flimsy tent where another homeless person was taking shelter.

A spokeswoman for the Union Gospel Mission, Courtney Dodds, said teams from her organization had been going out to try to persuade people to seek shelter.

“It can be really easy for people to doze off and fall asleep and wind up losing their lives because of the cold weather,” she said.

At famously snowy Buffalo, New York, forecasters predicted a “once-in-a-generation storm” because of heavy lake-effect snow, wind gusts as high as 65 mph, whiteouts and the potential for extensive power outages. Mayor Byron Brown urged people to stay home, and the NHL postponed the Buffalo Sabres’ home game against the Tampa Bay Lightning.

The area could see 2 to 4 feet of snow through the weekend, National Weather Service meteorologist Richard Otto said.

Denver, also no stranger to winter storms, was the coldest it has been in 32 years on Thursday, when the temperature dropped to minus 24 degrees in the morning at the airport.